Antidepressant Proposer 1.0

An application that evaluates 32 antidepressants based on 20 different patient factors and drug measures commonly encountered in practice. It allows for the selection of multiple attributes simultaneously and combines scores to generate an estimated overall suitability ranking. Detailed explanations for each attribute score are provided, along with references to UpToDate and other supporting primary literature sources.

• Citalopram
• Escitalopram
• Fluoxetine
• Fluvoxamine
• Paroxetine
• Sertraline
• Agomelatine
• Bupropion
• Mirtazapine
• Desvenlafaxine
• Levomilnacipran
• Milnacipran
• Venlafaxine
• Nefazodone
• Trazodone
• Vilazodone
• Vortioxetine
• Amitriptyline
• Amoxapine
• Clomipramine
• Desipramine
• Doxepin
• Imipramine
• Maprotiline
• Nortriptyline
• Protriptyline
• Trimipramine
• Isocarboxazid
• Phenelzine
• Selegiline
• Tranylcypromine
• Duloxetine

• Anticholinergic potential
• Drowsiness
• Insomnia/agitation
• Orthostatic hypotension risk
• QTc prolongation risk
• Gastrointestinal toxicity
• Weight gain propensity
• Sexual dysfunction risk
• Antidepressant-naive patient suitability
• Safety during pregnancy
• Safety during breastfeeding
• Efficacy in chronic pain management
• Risk of suicide as a result of overdose potential
• Treatment cost consideration
• Risk of drug-drug interactions
• Renal impairment considerations
• Hepatic impairment considerations
• Antidepressant efficacy for its primary indication
• All-cause discontinuation rate
• Discontinuation due to side effects rate